Likewise, the connection between article-medical NLR and you can stent restenosis wasn’t reviewed
Atherosclerosis is a progressive, complex and multifactorial disease. Inflammation plays an important role in all stages of the atherosclerosis development [13,14]. ISR has been attributed to neointimal hyperplasia in the early stage shortly after the procedure . Inflammatory cells may accelerate neointimal hyperplasia because of their release of growth and chemotactic factors or production of enzymes (e.g. matrix metalloproteinases), which can degrade extracellular constituents and facilitate cell migproportionn [17,18]. Neutrophils respond to different inflammatory stimuli resulting in release of various cytokines and cytotoxic/proteolytic enzymes that affect the vascular system by numerous mechanisms such as induction of damage to endothelial cells, induction of the coagulation system . Lymphocyte count reflects a physiologic stress response to cortisol . The NLR has been shown to be a mation and closely related to increased cardiovascular mortality and morbidity [5,6]. The primary finding of our study is that the NLRratio level was a better independent predictor than NLRafter level for the occurrence of the ISR in patients who underwent superficial femoral artery stenting for lower extremity arteriosclerosis obliterans. (more…)